Want to learn more about Singulex Technology? The following articles have been published in science journals by Singulex customers and collaborators.

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Cardiovascular
Date Title & Author(s) PMID
2015-Dec
Biomarkers and low risk in heart failure. Data from COACH and TRIUMPH

Meijers WC, de Boer RA, van Veldhuisen DJ, Jaarsma T, Hillege HL, Maisel AS, Di Somma S, Voors AA, Peacock WF

Eur J Heart Fail. 2015 Dec;17(12):1271-82. doi: 10.1002/ejhf.407. Epub 2015 Oct 14

[PMID: 26466857]
2015-Dec
Effects of Optimism and Gratitude on Physical Activity, Biomarkers, and Readmissions After an Acute Coronary Syndrome

Huffman JC, Beale EE, Celano CM, Beach SR, Belcher AM, Moore SV, Suarez L, Motiwala SR, Gandhi PU, Gaggin HK, Januzzi JL

Circ Cardiovasc Qual Outcomes. 2015 Dec 8. pii: CIRCOUTCOMES.115.002184.

[PMID: 26646818]
2015-Dec
Increased Mortality with Elevated Plasma Endothelin-1 in Acute Heart Failure: An ASCEND-HF Biomarker Sub-study

Perez AL, Grodin JL, Wu Y, Hernandez AF, Butler J, Metra M, Felker GM, Voors AA, McMurray JJ, Armstrong PW, Starling RC, O’Connor CM, Tang WH.

Eur J Heart Fail. 2015 Dec 14. doi: 10.1002/ejhf.456.

[PMID: 26663359]
2015-Dec
Optimizing clinical use of biomarkers in high-risk acute heart failure patients

Demissei BG, Valente MA, Cleland JG, O'Connor CM, Metra M, Ponikowski P, Teerlink JR, Cotter G, Davison B, Givertz MM, Bloomfield DM,Dittrich H, van der Meer P, van Veldhuisen DJ, Hillege HL , Voors AA.

Eur J Heart Fail. 2015 Dec 3. doi: 10.1002/ejhf.443.

[PMID: 26634889]
2015-Dec
The Development and Application of a High Sensitivity Immunoassay for Cardiac Myosin-Binding Protein C

Marjot J, Liebetrau C, Goodson RJ, Kaier T, Weber E, Heseltine P, Marber MS

Transl Res. 2015 Dec 8. pii: S1931-5244(15)00412-0. doi: 10.1016/j.trsl.2015.11.008.

[PMID: 26713894]
2015-Nov
Clinical benefit of high-sensitivity cardiac Troponin I in the detection of exercise-induced myocardial ischemia

Lee G, Twerenbold R, Tanglay Y, Reichlin T, Honegger U, Wagener M, Jaeger C, Gimenex MR, Hochgruber T, Puelacher C, Radosavac M, Kreutzinger P, Stallone F, Hillinger P, Krivoshei L, Herrmann T, Mayr R, Freese M, Wild D, Rentsch K, Todd J, Osswald S, Zellweger M, Mueller C.

American Heart Journal. 2015 Nov 20 doi: 10.1016/j.ahj.2015.11.010

2015-Nov
Plasma levels of glucagon-like peptide 1 and markers of obesity among young and healthy adults

Van der Stouwe JG, Aeschbacher S, Krisai P, Schoen T, Meyre P, Todd J, Estis J, Risch M, Risch L, Conen D

Clin Endocrinol (Oxf). 2015 Nov;83(5):636-42. doi: 10.1111/cen.12789. Epub 2015 Apr 27

[PMID: 25865948]
2015-Oct
Circulating Kidney Injury Molecule-1 Levels in Acute Heart Failure: Insights from the ASCEND-HF Trial

Grodin JL, Perez AL, Wu Y, Hernandez AF, Butler J, Metra M, Felker GM, Voors AA, McMurray JJ, Armstrong PW, Califf RM, Starling RC, O’Connor CM, Tang WH

JACC Heart Fail. 2015 Oct;3(10):777-85. doi: 10.1016/j.jchf.2015.06.006.

[PMID: 26449997]
2015-Oct
Plasma kidney injury molecule-1 in heart failure: renal mechanisms and clinical outcome

Emmens JE, Ter Maaten JM, Matsue Y, Metra M, O’Connor CM, Ponikowski P, Teerlink JR, Cotter G, Davison B, Cleland JG, Givertz MM, Bloomfield DM, Dittrich HC, Todd J, van Veldhuisen DJ, Hillege HL, Damman K, van der Meer P, Voors AA

Eur J Heart Fail. 2015 Oct 28. doi: 10.1002/ejhf.426.

[PMID: 26511274]
2015-Aug
A combined clinical and biomarker approach to predict diuretic response in acute heart failure

Ter Maaten JM, Valente MA, Metra M, Bruno N, O’Connor CM, Ponikowski P, Teerlink JR, Cotter G, Davison B, Cleland JG, Givertz MM, Bloomfield DM, Dittrick HC, van Veldhuisen DJ, Hillege HL, Damman K, Voors AA

Clin Res Cardiol. 2015 Aug 18.

[PMID: 26280875]
2015-Apr
Concentrations of Highly Sensitivity Cardiac Troponin-1 Predict Poor Cardiovascular Outcomes and Adverse Remodeling in Chronic Heart Failure

Motiwala SR, Gaggin HK, Gandhi PU, Belcher A, Weiner RB, Baggish AL, Szymonifka J, Januzzi JL Jr.

J Cardiovasc Transl Res. 2015 Apr;8(3):164-72. doi: 10.1007/s12265-015-9618-4. Epub 2015 Mar 17

[PMID: 25777344]
2015-Mar
Plasma endothelin-1 and cardiovascular risk among young and healthy adults

Bossard M, Pumpol K, van der Lely S, Aeschbacher S, Schoen T, Krisai P, Lam T, Todd J, Estis J, Risch M, Risch L, Conen D.

Atherosclerosis. 2015 Mar;239(1):186-91. doi: 10.1016/j.atherosclerosis.2014.12.061

[PMID: 25617859]
2015-Feb
Glucagon-like peptide-1 and blood pressure in young and healthy adults from the general population

Krisai P, Aeschbacher S, Schoen T, Bossard M, van der Stouwe JG, Dörig L, Todd J, Estis J, Risch M, Risch L, Conen D.

Hypertension. 2015 Feb;65(2):306-12. doi: 10.1161/HYPERTENSIONAHA.114.04718.

[PMID: 25452475]
2015-Jan
Clinically Significant Novel Biomarkers for Prediction of First Ever Myocardial Infarction: The Tromsø Study

Wilsgaard T, Mathiesen EB, Patwardhan A, Rowe MW, Schirmer H, Løchen ML, Sudduth-Klinger J, Hamren S, Bønaa KH, Njølstad I.

Circ Cardiovasc Genet. 2015 Jan 22. doi:113.000630.

[PMID: 25613532]
2015-Jan
Incremental value of a single high-sensitivity cardiac Troponin I measurement to rule-out myocardial ischemia

Tanglay Y1, Twerenbold R2, Lee G1, Wagener M1, Honegger U3, Puelacher C1, Reichlin T1, Sou SM2, Druey S1, Hochgruber T2, Zürcher S1, Radosavac M1,Kreutzinger P1, Pretre G1, Stallone F1, Hillinger P1, Jaeger C1, Gimenez MR1, Freese M1, Wild D4, Rentsch K5, Osswald S1, Zellweger MJ1, Mueller C6.

Am J Med. 2015 Jan 30. pii: S0002-9343(15)00081-9. doi: 10.1016/j.amjmed.2015.01.009.

[PMID: 25644323]
2014-Dec
Prognostic performance of a high-sensitivity assay for cardiac troponin I after non-ST elevation acute coronary syndrome: Analysis from MERLIN-TIMI 36

Bonaca MP, O'Malley RG, Murphy SA, Jarolim P, Conrad MJ, Braunwald E, Sabatine MS, Morrow DA.

Eur Heart J Acute Cardiovasc Care. 2014 Dec 23. pii: 2048872614564081.

[PMID: 25538086]
2014-Dec
Prognostic significance of active and modified forms of endothelin 1 in patients with heart failure with reduced ejection fraction

Gottlieb SS, Harris K, Todd J, Estis J, Christenson RH, Torres V, Whittaker K, Rebuck H, Wawrzyniak A, Krantz DS.

Clin Biochem. 2014 Dec 23. pii: S0009-9120(14)00795-4. doi: 10.1016/j.clinbiochem.2014.12.012.

[PMID: 25541019]
2014-Nov
Biomarkers of cardiovascular stress and subclinical atherosclerosis in the community

Gopal DM1, Larson MG2, Januzzi JL3, Cheng S4, Ghorbani A5, Wollert KC6, Kempf T6, D'Agostino RB2, Polak JF7, Ramachandran VS8, Wang TJ9, Ho JE10.

Clin Chem. 2014 Nov;60(11):1402-8. doi: 10.1373/clinchem.2014.227116. Epub 2014 Sep 18.

[PMID: 25237063]
2014-Nov
Relationship Between High-Sensitivity Cardiac Troponin I and Blood Pressure Among Young and Healthy Adults

Aeschbacher S, Schoen T, Bossard M, van der Lely S, Glättli K, Todd J, Estis J, Risch M, Mueller C, Risch L, Conen D.

Am J Hypertens. 2014 Nov 25. pii: hpu226.

[PMID: 25424717]
2014-Sep
Comprehensive biomarker profiling in patients with obstructive sleep apnea

Maeder MT, Strobel W, Christ M, Todd J, Estis J, Wildi K, Thalmann G, Hilti J, Brutsche M, Twerenbold R, Rickli H, Mueller C.

Clin Biochem. 2014 Sep 16. pii: S0009-9120(14)00662-6. doi: 10.1016/j.clinbiochem.2014.09.005.

[PMID: 25218814]
2014-Sep
High sensitivity cardiac troponin assays in the clinical laboratories

Jarolim P.

Clin Chem Lab Med. 2014 Sep 25. pii: /j/cclm.ahead-of-print/cclm-2014-0565/cclm-2014-0565.xml. doi: 10.1515/cclm-2014-0565.

[PMID: 25252753]
2014-Mar
Comparison of Three Troponins as Predictors of Future Cardiovascular Events - Prospective Results from the FINRISK and BiomaCaRE Studies

J. T. Neumann, A. S. Havulinna, T. Zeller, S. Appelbaum, T. Kunnas, S. Nikkari, P. Jousilahti, S. Blankenberg, K. Sydow and V. Salomaa

PLoS One. 2014 Mar 4;9(3):e90063. DOI: 10.1371/journal.pone.0090063. eCollection 2014.

2014-Feb
Cardiac Troponins and High-sensitivity Cardiac Troponin Assays

M. J. Conrad and P. Jarolim

Clin Lab Med. 2014 Mar;34(1):59-73, vi. DOI: 10.1016/j.cll.2013.11.008. Epub 2014 Jan 14.

[PMID: 24507787]
2013-Nov
Evaluation of the diagnostic performance of current and next-generation assays for cardiac troponin I in the BWH-TIMI ED Chest Pain Study

M. P. Bonaca, C. T. Ruff, J. Kosowsky, M. J. Conrad, S. A. Murphy, M. S. Sabatine, P. Jarolim and D. A. Morrow

Eur Heart J Acute Cardiovasc Care. 2013 Sep;2(3):195-202. DOI: 10.1177/2048872613486249.

[PMID: 24222830]
2013-Oct
Relation between soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I and incident atrial fibrillation

M. Rienstra, X. Yin, M. G. Larson, J. D. Fontes, J. W. Magnani, D. D. McManus, E. L. McCabe, E. E. Coglianese, M. Amponsah and J. E. Ho

Am Heart J. 2014 Jan;167(1):109-115.e2. DOI: 10.1016/j.ahj.2013.10.003. Epub 2013 Oct 17.

[PMID: 24332149]
2013-Aug
Analytical and assay issues for use of cardiac troponin testing for risk stratification in primary care

Wu AH, Christenson RH.

Clin Biochem. 2013 Aug;46(12):969-78
DOI: 10.1016/j.clinbiochem.2013.04.013

[PMID: 23623945]
2013-Jul
Biomarkers of Cardiovascular Stress and Incident Chronic kidney disease

Ho JE, Hwang SJ, Wollert KC, Larson MG, Cheng S, Kempf T, Vasan RS, Januzzi JL, Wang TJ, Fox CS.

Clin Chem. 2013 Jul 19 DOI: 10.1373/clinchem.2013.205716

[PMID: 23873716]
2013-Jun
Unstable Angina: Is It Time for a Requiem?

Braunwald E, Morrow DA

Circulation. 2013 Jun 18;127(24):2452-7
DOI: 10.1161/CIRCULATIONAHA.113.001258

[PMID: 23775194]
2013-Apr
T1 measurements identify extracellular volume expansion in hypertrophic cardiomyopathy sarcomere mutation carriers with and without left ventricular hypertrophy

C. Y. Ho, S. A. Abbasi, T. G. Neilan, R. V. Shah, Y. Chen, B. Heydari, A. L. Cirino, N. K. Lakdawala, E. J. Orav and A. Gonz√°lez

Circ Cardiovasc Imaging. 2013 May 1;6(3):415-22. DOI: 10.1161/CIRCIMAGING.112.000333. Epub 2013 Apr 2.

[PMID: 23549607]
2012-Nov
Darlapibid effect on circulating High sensitivity troponin in patients with acute coronary syndromes

García-García HM, Oemrawsingh RM, Brugaletta S, Vranckx P, Shannon J, Davies R, Boersma E, Serruys PW

Atherosclerosis. 2012 Nov;225(1):142-7
DOI: 10.1016/j.atherosclerosis.2012.06.064

[PMID: 22963982]
2012-Nov
Determination of 19 cardiac troponin I and T assay 99th percentile values from a common presumably healthy population

Apple FS, Ler R, Murakami MM

Clin Chem. 2012 Nov;58(11):1574-81
DOI: 10.1373/clinchem.2012.192716

[PMID: 22983113]
2012-Sep
Prognostic Utility of Novel Biomarkers of Cardiovascular Stress:The Framingham Heart Study

Wang TJ, Wollert KC, Larson MG, Coglianese E, McCabe EL, Cheng S, Ho JE, Fradley MG, Ghorbani A, Xanthakis V, Kempf T, Benjamin EJ, Levy D, Vasan RS, Januzzi JL.

Circulation. 2012 Sep 25;126(13):1596-604

[PMID: 22907935]
2012-Jul
Long-term biological variation in cardiac troponin I

Wu AH, Akhigbe P, Wians F.

Clin Biochem. 2012 Jul;45(10-11):714-6
DOI: 10.1016/j.clinbiochem.2012.03.008

2012-Jun
High-sensitivity cardiac troponin-I is elevated in patients with rheumatoid arthritis, independent of cardiovascular risk factors and inflammation

Bradham WS, Bian A, Oeser A, Gebretsadik T, Shintani A, Solus J, Estis J, Lu QA, Todd J, Raggi P, Stein CM.

PLoS One. 2012;7(6):e38930
DOI: 10.1371/journal.pone.0038930

[PMID: 22761714]
2012-Jun
Short-term (90min) diagnostic performance for acute non-ST segment elevation myocardial infarction and 30-day prognostic evaluation of a novel third-generation high sensitivity troponin I assay

Schreiber DH, Agbo C, Wu AH.

Clin Biochem. 2012 Nov;45(16-17):1295-301
DOI: 10.1016/j.clinbiochem.2012.06.005

[PMID: 22705845]
2012-May
Increased cardiac troponin I as measured by a high-sensitivity assay is associated with high odds of cardiovascular death: the Minnesota Heart Survey

Apple FS, Steffen LM, Pearce LA, Murakami MM, Luepker RV

Clin Chem. 2012 May;58(5):930-5
DOI: 10.1373/clinchem.2011.179176

[PMID: 22431895]
2012-Apr
Changes in cardiac biomarkers during doxorubicin treatment of pediatric patients with high-risk acute lymphoblastic leukemia: associations with long-term echocardiographic outcomes

Lipshultz SE, Miller TL, Scully RE, Lipsitz SR, Rifai N, Silverman LB, Colan SD, Neuberg DS, Dahlberg SE, Henkel JM, Asselin BL, Athale UH, Clavell LA, Laverdière C, Michon B, Schorin MA, Sallan SE.

J Clin Oncol. 2012 Apr 1;30(10):1042-9
DOI: 10.1200/JCO.2010.30.3404

[PMID: 22370326]
2011-Aug
A multicenter comparison of established and emerging cardiac biomarkers for the diagnostic evaluation of chest pain in the emergency department

Bhardwaj A, Truong QA, Peacock WF, Yeo KT, Storrow A, Thomas S, Curtis KM, Foote RS, Lee HK, Miller KF, Januzzi JL Jr.

Am Heart J. 2011 Aug;162(2):276-282.e1
DOI: 10.1016/j.ahj.2011.05.022

[PMID: 21835288]
2011-Apr
High-Sensitivity Cardiac Troponin for Screening Large Populations of Healthy People: Is There Risk?

Apple FS.

Clin Chem. 2011 Apr;57(4):537-9
DOI: 10.1373/clinchem.2011.162875

[PMID: 21310871]
2010-Oct
Troponin as a Biomarker of Cardiac Toxicity: Past, Present, and Future

Reagan WJ.

Toxicol Pathol. 2010 Dec;38(7):1134-7
DOI: 10.1177/0192623310382438

[PMID: 20884820]
2010-Jul
Defining the serum 99th percentile in a normal reference population measured by a high-sensitivity cardiac troponin I assay

Apple FS, Simpson PA, Murakami MM

Clin Biochem. 2010 Aug;43(12):1034-6
DOI: 10.1016/j.clinbiochem.2010.05.014

[PMID: 20510894]
2010-Mar
High-Sensitivity Cardiac Troponin: Hype, Help, and Reality

Jaffe AS, Apple FS.

Clin Chem. 2010 Mar;56(3):342-4
DOI: 10.1373/clinchem.2009.136218

[PMID: 20040616]
2009-Sep
Short- and Long-Term Cardiac Troponin I Analyte Stability in Plasma and Serum from Healthy Volunteers Using an Ultrasensitive, Single-Molecule Counting Assay

Wu AH, Shea E, Lu QT, Minyard J, Bui K, Hsu JC, Agee SJ, Todd J

Clin Chem. 2009 Nov;55(11):2057-9
DOI: 10.1373/clinchem.2009.128611

[PMID: 19729470]
2009-Jul
A New Season for Cardiac Troponin Assays: It's Time to keep a Scorecard

Apple FS.

Clin Chem. 2009 Jul;55(7):1303-6
DOI: 10.1373/clinchem.2009.128363

[PMID: 19478023]
2009-Mar
Interpretation of high sensitivity cardiac troponin I results: reference to biological variability in patients who present to the emergency room with chest pain: case report series

Wu AH

Clin Chim Acta. 2009 Mar;401(1-2):170-4
DOI: 10.1016/j.cca.2008.12.004

[PMID: 19135041]
2009-Feb
Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay: results from TIMI 35

Sabatine MS, Morrow DA, de Lemos JA, Jarolim P, Braunwald E

Eur Heart J. 2009 Jan;30(2):162-9
DOI: 10.1093/eurheartj/ehn504

[PMID: 18997177]
2009-Feb
Higher sensitivity troponin assays: Quo vadis?

Katus HA, Giannitsis E, Jaffe AS, Thygesen K

Eur Heart J. 2009 Jan;30(2):127-8
DOI: 10.1093/eurheartj/ehn555

[PMID: 19074444]
2009-Jan
Evaluation of High-Sensitivity Assays for Cardiac Troponin

Morrow DA, Antman EM

Clin Chem. 2009 Jan;55(1):5-8
DOI: 10.1373/clinchem.2008.117218

[PMID: 19028812]
2009-Jan
Refining Our Criteria: A Critical Challenge

Jaffe AS, Apple FS

Am J Clin Pathol. 2009 Jan;131(1):11-3
DOI: 10.1309/AJCPFYDY7B2AYDZE

[PMID: 19095560]
2009-Jan
Short- and Long-Term Biological Variation in Cardiac Troponin I Measured with a High-Sensitivity Assay: Implications for Clinical Practice

Wu AH, Lu QA, Todd J, Moecks J, Wians F

Clin Chem. 2009 Jan;55(1):52-8
DOI: 10.1373/clinchem.2008.107391

[PMID: 18988755]
2009-Jan
Specificity of a High-Sensitivity Cardiac Troponin I Assay Using Single-Molecule-Counting Technology

Wu AH, Agee SJ, Lu QA, Todd J, Jaffe AS

Clin Chem. 2009 Jan;55(1):196-8
DOI: 10.1373/clinchem.2008.108837

[PMID: 19106190]
2008-Dec
Ultrasensitive cross-species measurement of cardiac troponin-I using the Erenna immunoassay system

Schultze AE, Konrad RJ, Credille KM, Lu QA, Todd J

Toxicol Pathol. 2008 Oct;36(6):777-82
DOI: 10.1177/0192623308322016

[PMID: 18648092]
2008-Feb
The clinical need for high-sensitivity cardiac troponin assays for acute coronary syndromes and the role for serial testing

Wu AH, Jaffe AS

Am Heart J. 2008 Feb;155(2):208-14
DOI: 10.1016/j.ahj.2007.10.016

[PMID: 18215588]
2006-Nov
Development and preliminary clinical validation of a high sensitivity assay for cardiac troponin using a capillary flow (single molecule) fluorescence detector

Wu AH, Fukushima N, Puskas R, Todd J, Goix P

Clin Chem. 2006 Nov;52(11):2157-9

[PMID: 18061987]
Inflammation & Cytokines
Date Title & Author(s) PMID
2015-Dec
High altitude and acute mountain sickness and changes in circulating endothelin-1, interleukin-6 and interleukin-17a

Boos CJ, Woods DR, Varias A, Biscocho S, Heseltine P, Mellor AJ.

High Alt Med Biol. 2015 Dec 17.

[PMID: 26680502]
2015-Dec
Ustekinumab in hidradenitis suppurativa: clinical results and a search for potential biomarkers in serum

Blok JL, Li K, Brodmerkel C, Horvátovich P, Jonkman MF, Horváth B

Br J Dermatol. 2015 Dec 7. doi: 10.1111/bjd.14338.

[PMID: 26641739]
2015-Nov
Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis

Attur M, Statnikov A, Samuels J, Li Z, Alekseyenko AV, Greenberg JD, Krasnokutsky S, Rybak L, Lu QA, Todd J, Zhou H, Jordon JM, Kraus VB, Aliferis CF, Abramson SB

Osteoarthritis Cartilage. 2015 Nov;23(11):1915-24. doi: 10.1016/j.joca.2015.08.006

[PMID: 26521737]
2015-Aug
Development of an ultra-sensitive single molecule counting assay for the detection of interleukin-13 as a marker for asthmatic severity

Gaye B, Sikkema D, Lee TN

J Immunol Methods. 2015 Aug 15. pii: S0022-1759(15)30033-8. doi: 10.1016/j.jim.2015.08.006.

[PMID: 26284890]
2015-Feb
Increased Plasma IL-17F Levels in Rheumatoid Arthritis Patients Are Responsive to Methotrexate, Anti-TNF, and T Cell Costimulatory Modulation

Jain M1, Attur M, Furer V, Todd J, Ramirez R, Lock M, Lu QA, Abramson SB, Greenberg JD.

Inflammation. 2015 Feb;38(1):180-6. doi: 10.1007/s10753-014-0020-1.

[PMID: 25240765]
2014-Apr
Due diligence in the characterization of matrix effects in a total IL-13 SingulexTM method

Fraser S, Soderstrom C.

Bioanalysis. 2014 Apr;6(8):1123-9. doi: 10.4155/bio.14.42.

[PMID: 24830896]
2014-Apr
Guselkumab (an IL-23–specific mAb) demonstrates clinical and molecular response in patients with moderate-to-severe psoriasis

Howard Sofen, MD, Stacy Smith, MD, Robert T. Matheson, MD, Craig L. Leonardi, MD, Cesar Calderon, PhD, Carrie Brodmerkel, PhD, Katherine Li, MS, Kim Campbell, PhD, Stanley J. Marciniak Jr., MBA, Yasmine Wasfi, MD, PhD, Yuhua Wang, PhD, Philippe Szapary, MD, James G. Krueger, MD, PhD

J Allergy Clin Immunol. 2014 Apr;133(4):1032-40. DOI: 10.1016/j.jaci.2014.01.025.

[PMID: 24679469]
2014-Mar
Antibody-based proteomics and biomarker research - current status and limitations

Solier C1, Langen H.

Proteomics. 2014 Mar;14(6):774-83. doi: 10.1002/pmic.201300334.

[PMID: 24520068]
2013-Dec
Daclizumab, an IL-2 modulating antibody for treatment of multiple sclerosis

J. P. Sheridan, R. R. Robinson and J. W. Rose

Expert Rev Clin Pharmacol. 2014 Jan;7(1):9-19. DOI: 10.1586/17512433.2014.865516. Epub 2013 Dec 2.

[PMID: 24308792]
2013-Oct
Reference range and short- and long-term biological variation of interleukin (IL)-6, IL-17A and tissue necrosis factor-alpha using high sensitivity assays

J. Todd, P. Simpson, J. Estis, V. Torres and A. H. Wub

Cytokine. 2013 Dec;64(3):660-5. DOI: 10.1016/j.cyto.2013.09.018. Epub 2013 Oct 12.

[PMID: 24128872]
2013-Aug
Interleukin 17F Level and Interferon Beta Response in patients with multiple sclerosis

Hartung HP, Steinman L, Goodin DS, Comi G, Cook S, Filippi M, O'Connor P, Jeffery DR, Kappos L, Axtell R, Knappertz V, Bogumil T, Schwenke S, Croze E, Sandbrink R, Pohl C

JAMA Neurol. 2013 Aug;70(8):1017-21
DOI: 10.1001/jamaneurol.2013.192

[PMID: 23732754]
2013-Apr
Quantitative determination of human interleukin 22 (IL-22) in serum using Singulex Erenna® technology

Shukla R, Santoro J, Bender FC, Laterza OF

J Immunol Methods. 2013 Apr 30;390(1-2):30-4
DOI: 10.1016/j.jim.2013.01.002

[PMID: 23313291]
2011-Jul
IL-13 antibodies influence IL-13 clearance in humans by modulating scavenger activity of IL-13Rα2

Kasaian MT1, Raible D, Marquette K, Cook TA, Zhou S, Tan XY, Tchistiakova L.

J Immunol. 2011 Jul 1;187(1):561-9. doi: 10.4049/jimmunol.1100467.

[PMID: 21622864]
2011-May
Effects of Interleukin-13 Blockade on Allergen-induced Airway Responses in Mild Atopic Asthma

Gauvreau GM, Boulet LP, Cockcroft DW, FitzGerald JM, Carlsten C, Davis BE, Deschesnes F, Duong M, Durn BL, Howie KJ, Hui L, Kasaian MT, Killian KJ, Strinich TX, Watson RM, Y N, Zhou S, Raible D, O'Byrne PM.

Am J Respir Crit Care Med. 2011 Apr 15;183(8):1007-14
DOI: 10.1164/rccm.201008-1210OC

[PMID: 21057005]
2009-Oct
Analytical Validation of a Highly Sensitive Microparticle-Based Immunoassay for the Quantitation of IL-13 in Human Serum Using the Erenna® Immunoassay System

St Ledger K, Agee SJ, Kasaian MT, Forlow SB, Durn BL, Minyard J, Lu QA, Todd J, Vesterqvist O, Burczynski ME

J Immunol Methods. 2009 Oct 31;350(1-2):161-70
DOI: 10.1016/j.jim.2009.08.012

[PMID: 19732777]
Metabolism
Date Title & Author(s) PMID
2015-Feb
Glucagon-like peptide-1 and blood pressure in young and healthy adults from the general population

Krisai P, Aeschbacher S, Schoen T, Bossard M, van der Stouwe JG, Dörig L, Todd J, Estis J, Risch M, Risch L, Conen D.

Hypertension. 2015 Feb;65(2):306-12. doi: 10.1161/HYPERTENSIONAHA.114.04718.

[PMID: 25452475]
2014-May
Active glucagon-like peptide 1 quantitation in human plasma: a comparison of multiple ligand binding assay platforms

Fraser S, Dysinger M, Soderstrom C, Kuhn M, Durham R.

J Immunol Methods. 2014 May;407:76-81. doi: 10.1016/j.jim.2014.03.025. Epub 2014 Apr 8.

[PMID: 24721392]
2014-Jan
The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGFβ

C. S. Craft, T. A. Pietka, T. Schappe, T. Coleman, M. D. Combs, S. Klein, N. A. Abumrad and R. P. Mecham

Diabetes. 2014 Jun;63(6):1920-32. DOI: 10.2337/db13-1604. Epub 2014 Jan 23.

[PMID: 24458361]
2011-Dec
Microfluidic strategies applied to biomarker discovery and validation for multivariate diagnostics

Tarasow TM, Penny L, Patwardhan A, Hamren S, McKenna MP, Urdea MS.

Bioanalysis. 2011 Oct;3(19):2233-51
DOI: 10.4155/bio.11.224

[PMID: 21985417]
2009-Jul
Development of a Type 2 Diabetes Risk Model From a Panel of Serum Biomarkers From the Inter99 Cohort

Kolberg JA, Jørgensen T, Gerwien RW, Hamren S, McKenna MP, Moler E, Rowe MW, Urdea MS, Xu XM, Hansen T, Pedersen O, Borch-Johnsen K

Diabetes Care. 2009 Jul;32(7):1207-12
DOI: 10.2337/dc08-1935

[PMID: 19564473]
2009-May
Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life

Hines EP, White SS, Stanko JP, Gibbs-Flournoy EA, Lau C, Fenton SE

Mol Cell Endocrinol. 2009 May 25;304(1-2):97-105
DOI: 10.1016/j.mce.2009.02.021

[PMID: 19433254]
Neurology
Date Title & Author(s) PMID
2015-Sep
Cerebrospinal fluid VILIP-1 and YKL-40, candidate biomarkers to diagnose, predict and monitor Alzheimer's disease in a memory clinic cohort

Kester MI, Teunissen CE, Sutphen C, Herries EM, Ladenson JH, Xiong C, Scheltens P, van der Flier WM, Morris JC, Holtsman DM, Fagan AM

Alzheimers Res Ther. 2015 Sep 17;7(1):59. doi: 10.1186/s13195-015-0142-1

[PMID: 26383836]
2015-Apr
Cerebrospinal Fluid Markers of Neurodegeneration and Rates of Brain Atrophy in Early Alzheimer Disease

Rawan Tarawneh, MD; Denise Head, PhD; Samantha Allison, MA; Virginia Buckles, PhD; Anne M. Fagan, PhD; Jack H. Ladenson, PhD; John C. Morris, MD; David M. Holtzman, MD

JAMA Neurol. doi:10.1001/jamaneurol.2015.0202 Published online April 13, 2015.

2015-Apr
Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington’s disease patients

Edward J. Wild, Roberto Boggio, Douglas Langbehn, Nicola Robertson, Salman Haider, James R.C. Miller, Henrik Zetterberg, Blair R. Leavitt, Rainer Kuhn, Sarah J. Tabrizi, Douglas Macdonald, and Andreas Weiss

Journal of Clinical Investigation 2015 April 6 doi: 10.1172/JCI80743

2015-Mar
A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid

Yang T, O'Malley TT, Kanmet D, Jerecic J, Zieske L, Zetterberg H, Hyman BT, Walsh DM, Selkoe DJ

Alzheimers Res Ther. 2015 Mar 22;7(1):14. doi: 10.1186/s13195-015-0100-y

[PMID: PMC4369838]
2014-Mar
Longitudinal Change in CSF Biomarkers in Autosomal-Dominant Alzheimer's Disease

A. M. Fagan, C. Xiong, M. S. Jasielec, R. J. Bateman, A. M. Goate, T. L. Benzinger, B. Ghetti, R. N. Martins, C. L. Masters, R. Mayeux, J. M. Ringman, M. N. Rossor, S. Salloway, P. R. Schofield, R. A. Sperling, D. Marcus, N. J. Cairns, V. D. Buckles, J. H. Ladenson, J. C. Morris, D. M. Holtzman and N. Dominantly Inherited Alzheimer

Sci Transl Med. 2014 Mar 5;6(226):226ra30. DOI: 10.1126/scitranslmed.3007901.

[PMID: 24598588]
2014-Feb
A Sensitive β Oligomer Assay Discriminates Alzheimer's and Aged Control Cerebrospinal Fluid

M. J. Savage, J. Kalinina, A. Wolfe, K. Tugusheva, R. Korn, T. Cash-Mason, J. W. Maxwell, N. G. Hatcher, S. J. Haugabook and G. Wu

J Neurosci. 2014 Feb 19;34(8):2884-97. DOI: 10.1523/JNEUROSCI.1675-13.2014.

[PMID: 24553930]
2013-Oct
Pyroglutamate-Modified Amyloid-β Protein Demonstrates Similar Properties in an Alzheimer's Disease Familial Mutant Knock-In Mouse and Alzheimer's Disease Brain

G. Wu, R. A. Miller, B. Connolly, J. Marcus, J. Renger and M. J. Savage

Neurodegener Dis. 2014;14(2):53-66. DOI: 10.1159/000353634. Epub 2013 Oct 23.

[PMID: 24158021]
2013-Jan
Amyloid-beta oligomerization in Alzheimer Dimentia vs. high pathology controls

Esparza TJ, Zhao H, Cirrito JR, Cairns NJ, Bateman RJ, Holtzman DM, Brody DL

Ann Neurol. 2013 Jan;73(1):104-19
DOI: 10.1002/ana.23748

[PMID: 23225543]
2012-Mar
CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease

Tarawneh R, Lee JM, Ladenson JH, Morris JC, Holtzman DM.

Neurology. 2012 Mar 6;78(10):709-19
DOI: 10.1212/WNL.0b013e318248e568

[PMID: 22357717]
2011-Apr
Visinin-like protein-1: Diagnostic and prognostic biomarker in Alzheimer disease

Tarawneh R, D'Angelo G, Macy E, Xiong C, Carter D, Cairns NJ, Fagan AM, Head D, Mintun MA, Ladenson JH, Lee JM, Morris JC, Holtzman DM

Ann Neurol. 2011 Aug;70(2):274-85
DOI: 10.1002/ana.22448

[PMID: 21823155]
Toxicity
Date Title & Author(s) PMID
2014-Mar
The utility of serum biomarkers to detect myocardial alterations induced by Imatinib in rats

E. Herman, A. Knapton, J. Zhang, J. Estis, J. Todd and S. Lipshultz

Pharma Res Per, 2 (1), 2014. DOI: 10.1002/prp2.15

2013-Dec
Differential analysis of transient increases of serum cTnI in response to handling in rats

I. Mikaelian, M. E. Dunn, D. R. Mould, G. Hirkaler, W. Geng, D. Coluccio, R. Nicklaus, T. Singer and M. Reddy

Pharma Res Per, 1 (2), 2013. DOI: 10.1002/prp2.11

2013-Oct
The Influence of Age on Serum Concentrations of Cardiac Troponin I: Results in Rats, Monkeys, and Commercial Sera

Herman EH, Knapton A, Liu Y, Lipshultz SE, Estis J, Todd J, Woodward RA, Cochran T, Zhang J, Poirier MC

Toxicol Pathol. 2013 Oct 15
DOI: 10.1177/0192623313505154

[PMID: 24129761]
2013-Apr
An exploration of sunitinb-induced cardiotoxicity in male Sprague-Dawley rats

A. Knapton, E. Herman, J. Todd, J. Estis and J. Zhang

The FASEB Journal. 2013;27:652.1

2012-Jun
Myocardial mononuclear cell infiltrates are not associated with increased serum cardiac troponin I in cynomolgus monkeys

Dunn ME, Coluccio D, Zabka TS, Gopalakrishnan G, Hirkaler G, Geng W, Nicklaus R, Lipshultz SE, Doessegger L, Saladino BH, Singer T, Mikaelian I.

Toxicol Pathol. 2012 Jun;40(4):647-50
DOI: 10.1177/0192623311436176

[PMID: 22298795]
2011-Aug
Baseline serum cardiac troponin I concentrations in Sprague-Dawley, spontaneous hypertensive, Wistar, Wistar-Kyoto, and Fisher rats as determined with an ultrasensitive immunoassay

Herman E, Knapton A, Rosen E, Zhang J, Estis J, Agee SJ, Lu QA, Todd JA, Lipshultz SE.

Toxicol Pathol. 2011 Jun;39(4):653-63
DOI: 10.1177/0192623311406931

[PMID: 21558468]
2011-Jul
The implications of handling, restraint, anesthesia, and kinetics on cardiac Troponin I analysis in rats when utilizing an ultrasensitive immunoassay

Michael E. Dunn, Rachael Fernandes, Denise Coluccio, Rosemary Nicklaus, Gerard Hirkaler, Igor Mikaelian, Martin Sanders, Wanping Geng

"J of Pharmacological and Toxicological Methods Volume 64, Issue 1, July–August 2011, Pages e49–e50"

2011-Jan
Serum cardiac troponin I concentrations transiently increase in rats given rosiglitazone

Mikaelian I, Buness A, Hirkaler G, Fernandes R, Coluccio D, Geng W, Visalli T, Bachynsky MO, Berkofsky-Fessler W, Kanwal C, Hilton H, Nicklaus R, Hoflack JC, Dunn M, Sanders M, Giron M, Boyle BW, Singer T, Dick LS.

Toxicol Lett. 2011 Mar 5;201(2):110-5
DOI: 10.1016/j.toxlet.2010.12.012

[PMID: 21172411]
2010-Oct
Troponin as a Biomarker of Cardiac Toxicity: Past, Present, and Future

Reagan WJ.

Toxicol Pathol. 2010 Dec;38(7):1134-7
DOI: 10.1177/0192623310382438

[PMID: 20884820]
2009-Nov
Assessment of the toxicity of hydralazine using an ultrasensitive flow-based troponin immunoassay

Mikaelian I, Coluccio D, Hirkaler GM, Downing JC, Rasmussen E, Todd J, Estis J, Lu QA, Nicklaus R.

Toxicol Pathol. 2009 Dec;37(7):878-81
DOI: 10.1177/0192623309351894

[PMID: 19854888]
2009-Oct
Longitudinal Studies of Cardiac Troponin-I Concentrations in Serum from Male Sprague Dawley Rats: Baseline Reference Ranges and Effects of Handling and Placebo Dosing on Biological Variability

Schultze AE, Carpenter KH, Wians FH, Agee SJ, Minyard J, Lu QA, Todd J, Konrad RJ

Toxicol Pathol. 2009 Oct;37(6):754-60
DOI: 10.1177/0192623309343777

[PMID: 19700656]
2008-Feb
The clinical need for high-sensitivity cardiac troponin assays for acute coronary syndromes and the role for serial testing

Wu AH, Jaffe AS

Am Heart J. 2008 Feb;155(2):208-14
DOI: 10.1016/j.ahj.2007.10.016

[PMID: 18215588]
Technology
Date Title & Author(s) PMID
2015-Jan
Emerging technologies to increase ligand binding assay sensitivity

Fischer SK, Joyce A, Spengler M, Yang TY, Zhuang Y, Fjording MS, Mikulskis A.

AAPS J. 2015 Jan;17(1):93-101. doi: 10.1208/s12248-014-9682-8.

[PMID: 25331105]
2013-Sep
Diagnosis of acute myocardial infarction: super-sensitivity vs. high-sensitivity cardiac troponin I assay

F. Brunner, N. Schofer, M. Schlueter, F. Ojeda, T. Zeller, C. Bickel, T. Muenzel, T. Keller, S. Blankenberg and B. Goldmann

Eur Heart J (2013) 34 (suppl 1). DOI: 10.1093/eurheartj/eht310.P5534

2011-May
Introduction to Biomarkers

Litwin V, Marder P, Vesterqvist O, Reddy M.P.

Book Chapter: Flow Cytometry in Drug Discovery and Development. (55-68)
DOI: 10.1002/9780470910085.ch3

2007-Sep
Ultrasensitive Flow-based Immunoassays by Use of Single-Molecule Counting

Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P

Clin Chem. 2007 Nov;53(11):1990-5

[PMID: 17890441]
2006-Nov
Development and preliminary clinical validation of a high sensitivity assay for cardiac troponin using a capillary flow (single molecule) fluorescence detector

Wu AH, Fukushima N, Puskas R, Todd J, Goix P

Clin Chem. 2006 Nov;52(11):2157-9

[PMID: 18061987]