Scientific Publications
Want to learn more about Singulex Technology? The following journal articles have been published with our collaborators.
Peer Reviewed Articles
| 2012-Sep-11 |
Prognostic Utility of Novel Biomarkers of Cardiovascular Stress:The Framingham Heart Study.
Wang TJ, Wollert KC, Larson MG, Coglianese E, McCabe EL, Cheng S, Ho JE, Fradley MG, Ghorbani A, Xanthakis V, Kempf T, Benjamin EJ, Levy D, Vasan RS, Januzzi JL.
Circulation. 2012 Aug 20.
10.1161/ |
[PMID: 22907935] |
| 2012-Jul-30 |
Long-term biological variation in cardiac troponin I.
Wu AH, Akhigbe P, Wians F.
Clin Biochem. 2012 Jul;45(10-11):714-6.
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[PMID: 22449338] |
| 2012-Jun-30 |
Myocardial mononuclear cell infiltrates are not associated with increased serum cardiac troponin I in cynomolgus monkeys.
Dunn ME, Coluccio D, Zabka TS, Gopalakrishnan G, Hirkaler G, Geng W, Nicklaus R, Lipshultz SE, Doessegger L, Saladino BH, Singer T, Mikaelian I.
Toxicol Pathol. 2012 Jun;40(4):647-50.
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[PMID: 22298795] |
| 2012-Jun-28 |
High-sensitivity cardiac troponin-I is elevated in patients with rheumatoid arthritis, independent of cardiovascular risk factors and inflammation.
Bradham WS, Bian A, Oeser A, Gebretsadik T, Shintani A, Solus J, Estis J, Lu QA, Todd J, Raggi P, Stein CM.
PLoS One. 2012;7(6):e38930.
|
[PMID: 22761714] |
| 2012-Jun-15 |
Short-term (90min) diagnostic performance for acute non-ST segment elevation myocardial infarction and 30-day prognostic evaluation of a novel third-generation high sensitivity troponin I assay.
Schreiber DH, Agbo C, Wu AH.
Clin Biochem. 2012 Jun 15
|
[PMID: 22705845] |
| 2012-May-30 |
Increased cardiac troponin I as measured by a high-sensitivity assay is associated with high odds of cardiovascular death: the Minnesota Heart Survey
Apple FS, Steffen LM, Pearce LA, Murakami MM, Luepker RV
Clin Chem. 2012 May;58(5):930-5.
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[PMID: 22431895] |
| 2012-Apr-30 |
Changes in cardiac biomarkers during doxorubicin treatment of pediatric patients with high-risk acute lymphoblastic leukemia: associations with long-term echocardiographic outcomes
Lipshultz SE, Miller TL, Scully RE, Lipsitz SR, Rifai N, Silverman LB, Colan SD, Neuberg DS, Dahlberg SE, Henkel JM, Asselin BL, Athale UH, Clavell LA, Laverdičre C, Michon B, Schorin MA, Sallan SE.
J Clin Oncol. 2012 Apr 1;30(10):1042-9.
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[PMID: 22370326] |
| 2012-Mar-06 |
CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease.
Tarawneh R, Lee JM, Ladenson JH, Morris JC, Holtzman DM.
Neurology. 2012 Mar 6;78(10):709-19.
|
[PMID: 22357717] |
| 2011-Dec-01 |
Microfluidic strategies applied to biomarker discovery and validation for multivariate diagnostics
Theodore M Tarasow, Laura Penny, Anil Patwardhan, Sarah Hamren, Michael P McKenna, Mickey S Urdea
Bioanalysis, October 2011, Vol. 3, No. 19, Pages 2233-2251.
doi:10.4155/bio.11.224 |
[PMID: 21985417] |
| 2011-Oct-30 |
The complete pharmacokinetic profile of serum cardiac troponin I in the rat and the dog.
Dunn ME, Coluccio D, Hirkaler G, Mikaelian I, Nicklaus R, Lipshultz SE, Doessegger L, Reddy M, Singer T, Geng W.
Toxicol Sci. 2011 Oct;123(2):368-73
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[PMID: PMID: 21775726] |
| 2011-Sep-23 |
A Multifaceted Evaluation of Imatinib-induced Cardiotoxicity in the Rat
Herman EH, Knapton A, Rosen E, Thompson K, Rosenzweig B, Estis J, Agee S, Lu QA, Todd JA, Lipshultz S, Hasinoff B, Zhang J.
Toxicol Pathol. 2011 Sep 21. [Epub ahead of print]
DOI: 10.1177/0192623311419524
Area of Focus: Toxicity
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[PMID: 21937741] |
| 2011-Aug-04 |
Baseline serum cardiac troponin I concentrations in sprague-dawley, spontaneous hypertensive, Wistar, Wistar-Kyoto, and Fisher rats as determined with an ultrasensitive immunoassay.
Herman E, Knapton A, Rosen E, Zhang J, Estis J, Agee SJ, Lu QA, Todd JA, Lipshultz SE.
Toxicol Pathol. 2011 Jun;39(4):653-63. Epub 2011 May 10.
10.1177/0192623311406931 |
[PMID: 21558468] |
| 2011-Jul-30 |
The implications of handling, restraint, anesthesia, and kinetics on cardiac Troponin I analysis in rats when utilizing an ultrasensitive immunoassay.
Dunn, M.E., Fernandes, R., Coluccio, D., Nicklaus, R., Hirkaler, G., Mikaelian, I., Sanders, M., Geng, W.,
Journal of Pharmacological and Toxicological Methods
10.1016/j.vascn.2011.03.172 |
[PMID: ] |
| 2011-May-24 |
Introduction to Biomarkers
Vesterqvist O, Reddy MP. In V. Litwin and P. Marder (Eds.).
Flow Cytometry in Drug Discovery and Development. (55-68). Wiley & Sons. 2001
10.1002/9780470910085.ch3 |
[PMID: ] |
| 2011-May-13 |
Effects of Interleukin-13 Blockade on Allergen-induced Airway Responses in Mild Atopic Asthma.
Gauvreau GM, Boulet LP, Cockcroft DW, Fitzgerald JM, Carlsten C, Davis BE, Deschesnes F, Duong M, Durn BL, Howie KJ, Hui L, Kasaian MT, Killian KJ, Strinich TX, Watson RM, Y N, Zhou S, Raible D, O'Byrne PM.
Am J Respir Crit Care Med. 2011 Apr 15;183(8):1007-14. Epub 2010 Nov 5.
10.1164/rccm.201008-1210OC |
[PMID: 21057005] |
| 2011-Apr-12 |
High-Sensitivity Cardiac Troponin for Screening Large Populations of Healthy People: Is There Risk?
Apple FS.
Clin Chem. 2011 Apr;57(4):537-9. Epub 2011 Feb 10.
10.1373/clinchem.2011.162875 |
[PMID: 21310871] |
| 2011-Apr-11 |
Visinin-like protein-1: Diagnostic and prognostic biomarker in Alzheimer disease
Rawan Tarawneh, Gina D'Angelo, Elizabeth Macy , Chengjie Xiong , Deborah Carter , Nigel J. Cairns, Anne M. Fagan, Denise Head , Mark A. Mintun, Jack H. Ladenson, Jin-Moo Lee, John C. Morris, David M. Holtzman
Annals of Neurology Accepted Articles, Accepted manuscript online: 7 APR 2011
10.1002/ana.22448 |
[PMID: 10.1002/ana.22448] |
| 2011-Jan-19 |
Serum cardiac troponin I concentrations transiently increase in rats given rosiglitazone.
Mikaelian I, Buness A, Hirkaler G, Fernandes R, Coluccio D, Geng W, Visalli T, Bachynsky MO, Berkofsky-Fessler W, Kanwal C, Hilton H, Nicklaus R, Hoflack JC, Dunn M, Sanders M, Giron M, Boyle BW, Singer T, Dick LS.
Toxicol Lett. 2010 Dec 21. [Epub ahead of print]
doi:10.1016/j.toxlet.2010.12.012 |
[PMID: 21172411] |
| 2010-Oct-28 |
Troponin as a Biomarker of Cardiac Toxicity: Past, Present, and Future.
William J. Reagan DVM PhD Dipl ACVP, DVM PhD, DACVP
Toxicol Pathol. 2010 Sep 30. [Epub ahead of print]
10.1177/0192623310382438 |
[PMID: 20884820] |
| 2010-Jul-22 |
Defining the serum 99th percentile in a normal reference population measured by a high-sensitivity cardiac troponin I assay.
Apple FS, Simpson PA, Murakami MM.
Clin Biochem. 2010 Aug;43(12):1034-6. Epub 2010 May 27.
doi:10.1016/j.clinbiochem.2010.05.014 |
[PMID: 20510894] |
| 2010-Mar-10 |
High-Sensitivity Cardiac Troponin: Hype, Help, and Reality.
Jaffe AS, Apple FS.
Clin Chem. 2010 Mar;56(3):342-4. Epub 2009 Dec 29.
10.1373/clinchem.2009.136218 |
[PMID: 20040616] |
| 2009-Nov-06 |
Assessment of the cardiotoxicity of hydralazine using an ultrasensitive flow-based troponin immunoassay.
Igor Mikaelian, Denise Coluccio, Gerard Hirkaler, John C. Downing, Erik Rasmussen, Todd, John, Joel Estis, Quynh Anh Lu, Rosemary Nicklaus
Toxicol Pathol, 2009; 37(7):878-81.
doi:10.1177/0192623309351894 |
[PMID: 19854888] |
| 2009-Oct-20 |
Analytical Validation of a Highly Sensitive Microparticle-Based Immunoassay for the Quantitation of IL-13 in Human Serum Using the ErennaŽ Immunoassay System
Katie St. Ledger, Sara J. Agee, Marion Kasain, Stephen B. Forlow, Billie L. Durn, Jennifer Minyard, Quynh Anh Lu, John Todd, Ole Vesterqvist, and Michael Burczynski.
J Immunol Methods, 2009;350(1-2):161-70
doi:10.1016/j.jim.2009.08.012 |
[PMID: 19732777] |
| 2009-Oct-20 |
Longitudinal Studies of Cardiac Troponin-I Concentrations in Serum from Male Sprague Dawley Rats: Baseline Reference Ranges and Effects of Handling and Placebo Dosing on Biological Variability
A. Eric Schultze, Kent H. Carpenter, Frank H. Wians, Sara J. Agee, Jennifer Minyard, Quynh Anh Lu, John Todd, and Robert J. Konrad.
Toxicol Pathol, 2009;37(6):754-60.
doi: 10.1177/0192623309343777 |
[PMID: 19700656] |
| 2009-Sep-18 |
Short- and Long-Term Cardiac Troponin I Analyte Stability in Plasma and Serum from Healthy Volunteers Using an Ultrasensitive, Single-Molecule Counting Assay.
Wu AH, Shea E, Thuc Lu Q, Minyard J, Bui K, Hsu JC, Agee SJ, Todd J.
Clin Chem.2009; 0: clinchem.2009.128611v1 Epub 2009 Sept 3.
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[PMID: 19729470] |
| 2009-Jul-15 |
A New Season for Cardiac Troponin Assays: It's Time to keep a Scorecard
Fred S. Apple
Clin Chem. 2009 Jul;55(7):1303-6
doi:10.1373/clinchem.2009.128363 |
[PMID: 19478023] |
| 2009-Jul-10 |
Development of a Type 2 Diabetes Risk Model From a Panel of Serum Biomarkers From the Inter99 Cohort.
Kolberg JA, Jřrgensen T, Gerwien RW, Hamren S, McKenna MP, Moler E, Rowe MW, Urdea MS, Xu XM, Hansen T, Pedersen O, Borch-Johnsen K.
Diabetes Care. 2009 Jul;32(7):1207-12.
doi: 10.2337/dc08-1935 |
[PMID: 19564473] |
| 2009-May-21 |
Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life.
Hines EP, White SS, Stanko JP, Gibbs-Flournoy EA, Lau C, Fenton SE.
Mol Cell Endocrinol. 2009 May 25;304(1-2):97-105. Epub 2009 Mar 9.
doi:10.1016/j.mce.2009.02.021 |
[PMID: 19433254] |
| 2009-Mar-10 |
Interpretation of high sensitivity cardiac troponin I results: reference to biological variability in patients who present to the emergency room with chest pain: case report series.
Wu AH.
Clin Chim Acta. 2009 Mar;401(1-2):170-4. Epub 2008 Dec 10.
doi:10.1016/j.cca.2008.12.004 |
[PMID: 19135041] |
| 2009-Feb-23 |
Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay: results from TIMI 35.
Marc S. Sabatine, David A. Morrow, James A. de Lemos, Petr Jarolim, and Eugene Braunwald.
Eur Heart J 2009 Jan;30(2):162-9.
doi:10.1093/eurheartj/ehn504 |
[PMID: 18997177] |
| 2009-Feb-23 |
Higher sensitivity troponin assays: Quo vadis?
H. A. Katus, E. Giannitsis, A. S. Jaffe, and K. Thygesen.
Eur Heart J 2009 Jan;30(2):127-8.
doi:10.1093/eurheartj/ehn504 |
[PMID: 19074444] |
| 2009-Jan-30 |
Specificity of a High-Sensitivity Cardiac Troponin I Assay Using Single-Molecule-Counting Technology
Wu, A. H.B., Agee, S. J., Lu, Q. A., Todd, J., Jaffe, A. S.
Clin Chem 2009 Jan, 55(1):196-8.
doi:10.1373/clinchem.2008.108837 |
[PMID: 19106190] |
| 2009-Jan-30 |
Short- and Long-Term Biological Variation in Cardiac Troponin I Measured with a High-Sensitivity Assay: Implications for Clinical Practice
Wu, A. H.B., Lu, Q. A., Todd, J., Moecks, J., Wians, F.
Clin Chem 2009 Jan;55(1):52-8. Epub 2008 Nov 6.
doi:10.1373/clinchem.2008.107391 |
[PMID: 18988755] |
| 2009-Jan-20 |
Refining Our Criteria: A Critical Challenge
Jaffe AS, Apple FS.
Am J Clin Pathol. 2009 Jan;131(1):11-3
10.1309/AJCPFYDY7B2AYDZE |
[PMID: 19095560] |
| 2009-Jan-10 |
Evaluation of High-Sensitivity Assays for Cardiac Troponin
Morrow DA, Antman EM.
Clin Chem. 2009 Jan;55(1):5-8. Epub 2008 Nov 21.
doi:10.1373/clinchem.2008.117218 |
[PMID: 19028812] |
| 2008-Dec-03 |
Ultrasensitive cross-species measurement of cardiac troponin-I using the Erenna immunoassay system.
A. Eric Schultze, Robert J. Konrad, Kelly M. Credille, Quynh Anh Lu and John Todd
Toxicol Pathol 2008;36(6):777-82. Epub 2008 Jul 22.
doi:10.1177/0192623308322016 |
[PMID: 18648092] |
| 2008-Feb-19 |
The clinical need for high-sensitivity cardiac troponin assays for acute coronary syndromes and the role for serial testing.
Alan H.B. Wu and Allan S. Jaffe
Am Heart J 2008 Feb;155(2):208-14. Epub 2007 Dec 19.
doi:10.1016/j.ahj.2007.10.016 |
[PMID: 18215588] |
| 2007-Sep-21 |
Ultrasensitive Flow-based Immunoassays by Use of Single-Molecule Counting.
John Todd, Bob Freese, Ann Lu, Douglas Held, Jennifer Morey, Richard Livingston, Philippe Goix
Clin Chem 2007 Nov; 53(11):1990-5. Epub 2007 Sep 21.
doi:10.1373/clinchem.2007.091181 |
[PMID: 17890441] |
| 2006-Nov-01 |
Development and preliminary clinical validation of a high sensitivity assay for cardiac troponin using a capillary flow (single molecule) fluorescence detector.
Alan H B Wu, Noelle Fukushima, Robert Puskas, John Todd, Philippe Goix
Clin Chem 2006 Nov; 52(11): 2157-9.
doi:10.1373/clinchem.2006.073163 |
[PMID: 18061987] |
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