Lower Limit of Detection |
0.005 pg/mL |
Lower Limit of Quantification2 |
0.2 pg/mL |
Upper Limit of Quantification |
100 pg/mL |
Low-end CV% Range |
1 - 11% |
Low-end CV% Average |
7% |
Recommended Sample Volume |
50 μL |
Minimum Sample Volume Required3 |
50 μL |
Representative data shown for demonstration purposes only. Individual results may vary depending upon samples tested and protocol used.
Interleukin-21 (IL-21) is a cytokine with a potent regulatory effect on the immune system. Mainly produced by activated T-cells, IL-21 is responsible for the hematopoiesis of T-, B-, natural killer and dendritic cells. The production and differentiation of these effector cells may lead to an increased immunity against cancerous or virally infected cells. Thus, the role of IL-21 in the regulation of immuno-inflammatory responses has important implications for diseases such as multiple sclerosis, metastatic melanoma and metastatic renal cell carcinoma. Thus IL-21 will remain an attractive subject for drug development. Successful study outcomes will further establish IL-21 immunotherapy as an effective treatment for various cancers and inflammatory diseases.
Protein Name: |
Interleukin-21 |
UniProtKB/Swiss-Prot ID: |
Q9HBE4 |
Protein-protein interaction database: |
Q9HBE4 |
Alternative Names: |
Za11 |
Gene Names: |
IL21 |
Synonym Gene Names: |
|
Function: |
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells By similarity. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. |
Biological Processes: |
cell maturation, immune response, positive regulation of T cell proliferation, positive regulation of interferon-gamma biosynthetic process, signal transduction |
Molecular Function: |
cytokine activity, interleukin-2 receptor binding |
|
G-CSF |
Erenna® G-CSF Immunoassay Kit |
03-0047-xx |
GM-CSF |
Erenna® GM-CSF Immunoassay Kit |
03-0067-xx |
IFN-γ |
Erenna® IFN-γ Immunoassay Kit |
03-0049-xx |
IL-1α |
Erenna® IL-1α Immunoassay Kit |
03-0050-xx |
IL-1β |
Erenna® IL-1β Immunoassay Kit |
03-0030-xx |
IL-10 |
Erenna® IL-10 Immunoassay Kit |
03-0056-xx |
IL-12 |
Erenna® IL-12 Immunoassay Kit |
03-0057-xx |
IL-13 |
Erenna® IL-13 Immunoassay Kit |
03-0069-xx |
IL-15 |
Erenna® IL-15 Immunoassay Kit |
03-0058-xx |
IL-17A |
Erenna® IL-17A Immunoassay Kit |
03-0017-xx |
IL-17A/F Heterodimer |
Erenna® IL-17A/F Heterodimer Immunoassay Kit |
03-0073-xx |
IL-17F |
Erenna® IL-17F Immunoassay Kit |
03-0018-xx |
IL-2 |
Erenna® IL-2 Immunoassay Kit |
03-0051-xx |
IL-22 |
Erenna® IL-22 Immunoassay Kit |
03-0059-xx |
IL-4 |
Erenna® IL-4 Immunoassay Kit |
03-0052-xx |
IL-5 |
Erenna® IL-5 Immunoassay Kit |
03-0053-xx |
IL-6 |
Erenna® IL-6 Immunoassay Kit |
03-0010-xx |
IL-8 |
Erenna® IL-8/CXCL8 Immunoassay Kit |
03-0055-xx |
TNFα (human) |
Erenna® Human TNFα Immunoassay Kit |
03-0022-xx |
VEGF-A (human) |
Erenna® Human VEGF Immunoassay Kit |
03-0068-xx |