Erenna^® Immunoassay System

Singulex has developed the Erenna Immunoassay System, which leads the next generation of molecular diagnostic technologies capable of quantifying biomarkers at the sub-picogram level. The Erenna Immunoassay System utilizes paramagnetic microparticles (MPs) as the solid phase for capture and detection of analyte from a complex biological sample, providing enhanced specificity, sensitivity and precision by 1-3 logs over existing plate-based methods.

The Erenna Immunoassay System consists of 2 major steps: a modified microparticle (MP) based sandwich immunoassay followed by single-molecule counting (SMC) technology. The system integrates capillary flow, laser-induced fluorescence, a highly sensitive detection optics module, and a 384-well plate format for sample analysis.

The Erenna Immunoassay System incorporates a robust digital molecule-counting module to count photons, where ultra-sensitive fluorescence is measured in the presence of proprietary background reduction methodology. A large dynamic range of 4+ logs is obtained by combining single-molecule counting (low range) with photon counting (mid range) and total light measurements (high range).

The Erenna Immunoassay System includes a fully equipped bench-top analytical instrument, a set of integrated and prepared reagents in micro-titer plate format, and data management software to automatically display detailed assay reports in a user-friendly format. This reliable, easy-to-use, walk-away system produces results from biological specimens like serum or plasma in as little as one hour.

The Erenna Immunoassay System is for research use only. Read our pilot studies to learn more about our technology.

For more information about our assay services and partnering opportunities, please email our business development at busdev@singulex.com or call us at 1-510-995-9040.